If you visit is to generally enjoy all the major sites (Vatican, Colosseum, Spanish Steps, P. Navona, Spanis Steps, etc), then you want to be either in the Historic Centre, or, to save a little money or have a little more space, just outside it.
The Historic Centre is the area in the centre of Rome that holds 90% of the significant tourist sites. It is called the Historic Centre (Centro Storico), because it is the area that has been inhabited, almost without a break, for over 2000 years. Buildings and sites are generally dated between 2000 and 300 years old.

Just outside the historic centre, is the more 20th Century Rome. This area, on the edge of the Historic Centre, is where most buildings are between 40-100 Years old.
However, many people contend that accommodation in the very centre is both a key part of their enjoyment of Rome, and avoids any travel time.

Best Hotels in Rome

Hotel Dei Mellini This luxury hotel welcomes guests in a prestigious 19th-century building situated in the city centre near the Vatican. The nearby underground station provides quick and easy access to rest of Rome and all its most celebrated monuments. More details    Hotel reviews € 130 per room - per night   Hotel Roma Boutique It is an exclusively modern designed Hotel located on the fourth floor of a beautiful building dating back to the beginning of the century. Few steps away from the Spanish Steps and Via Veneto, the famous street that inspired Federico Fellini in his famous movie 'La Dolce Vita’. More details    Hotel reviews € 110 per room - per night   Hotel Imperial Rooms It is superbly located facing the magnificent Colosseum in the heart of Rome's city center. The Imperial Rooms is well connected with public transport like buses or metro. More details    Hotel reviews € 70 per room - per night   Hotel St.Moritz This is the perfect location to see Rome by foot or by public transport. Termini train station is just meters away, along with many of Rome’s famous monuments. More Details    Hotel reviews € 60 per room - per night   Hotel Soggiorno Blu The hotel is in a very good position for sightseeing, visiting museums and walking in the centre of the town. This Hotel is also a very good choice for budget travellers. More details    Hotel reviews € 45 per room - per night   Hotel Clarin Located in the heart of the city almost everything is in walking distance from monuments, museums, shopping and night life. More details    Hotel reviews € 45 per room - per night

It is really impossible to get the best of Rome on just a short notice. You need to have few days of staying in order to enjoy Rome. Budget hotels should be your first choice. This should not be a problem since the hotels in Rome can come as cheap as you want or as expensive as you want. When you book a discount hotel, Rome can be really easy to follow around and everyday, you will have a new adventure.
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